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1994-10-25
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Document 2955
DOCN M94A2955
TI AIDS associated diarrhea. Preliminary results of a study.
DT 9412
AU Tumbarello M; Ventura G; Tacconelli E; Scoppettuolo G; Papi G; Cauda R;
Istituto Malattie Infettive, Universita Cattolica Roma, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):187 (abstract no. PB0175). Unique
Identifier : AIDSLINE ICA10/94369620
AB OBJECTIVE: To evaluate the frequency, microbiological agents, clinical
findings and impact on the quality of life of diarrhea in AIDS patients
(pts). METHODS: All consecutive AIDS pts admitted to our ward from
7-1993 to 2-1994 were included in the study. Diarrhea was defined as 3
or more daily bowel movements for more than 2 consecutive days. From
each pts with diarrhea stool samples were screened for bacteria and
parasites. An adapted version of the Functional Living Index for Cancer
test was used to evaluate the quality of life in AIDS pts with (group A)
or without (group B) diarrhea in comparison to a randomly selected group
of HIV asymptomatic individuals (group C). RESULTS: 44 patients with
AIDS related diarrhea were observed (29 M and 15 F, mean age 32 +/- 4
yrs.). In 24 patients diarrhea was related to one or more enteric
pathogens, namely Cryptosporidium (29%), NT-Salmonella (21%),
Mycobacterium avium complex (21%), C. difficile (17%) and Campylobacter
(12.5%). No specific agent responsible of diarrhea was identified in 45%
of the cases. The response to antimicrobial therapy was favorable in 68%
of cases. 11 patients with refractory diarrhea were treated with
antidiarrhoeal therapy, i.e. loperamide or octeotride. The quality of
life resulted low in group A and B (p < 0.05 versus group C); in
particular, the pts of group A had the lower quality of life (p = ns
versus group B). CONCLUSIONS: These preliminary data suggest that
diarrhea is a rilevant issue that can negatively influences the quality
of life of AIDS pts.
DE Adult AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY/
*ETIOLOGY Diagnosis, Differential Diarrhea/DRUG THERAPY/*ETIOLOGY
Female Human Loperamide/THERAPEUTIC USE Male Octreotide/THERAPEUTIC
USE Quality of Life MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).